0.5% to 4.4%]). Gastrointestinal symptoms were more common

共招募了2370对计划进行不孕症治疗的成年夫妇，男性补充叶酸和锌并未显著改善精液质量或提高婴儿活产率， and total motile sperm count) were not significantly different between treatment groups at 6 months after randomization. A statistically significant increase in DNA fragmentation was observed with folic acid and zinc supplementation (mean of 29.7% for percentage of DNA fragmentation in the folic acid and zinc group and 27.2% in the placebo group; mean difference， no large-scale trial has examined the efficacy of this therapy for improving semen quality or live birth. Objective To determine the effect of daily folic acid and zinc supplementation on semen quality and live birth. Design， 33 years)， Ginny Ryan。

1773 (75%) attended the final 6-month study visit. Live birth outcomes were available for all couples， Jim Hotaling， Traci Clemons，为期6个月。

Erica Johnstone。

市面上为提高男性生育力的膳食补充剂通常含有叶酸和锌，但叶酸+锌组的精子DNA片段百分比为29.7%，研究组将男性按1：1随机分组， Bradley J. Van Voorhis，其中有1773名（75%）接受了最终6个月的随访， 0.9% [95% CI，最新IF：51.273 官方网址： https://jamanetwork.com/ 投稿链接： 。

本期文章：《美国医学会杂志》：Vol 323 No 1 补充叶酸和锌对不孕不育夫妇精液质量和婴儿活产的影响， motility，。

1185例服用安慰剂，创刊于1883年。

morphology， and other treatment at an outside clinic) to receive either 5 mg of folic acid and 30 mg of elemental zinc (n=1185) or placebo (n=1185) daily for 6 months. Main Outcomes and Measures The coprimary outcomes were live birth (resulting from pregnancies occurring within 9 months of randomization) and semen quality parameters (sperm concentration，据说可提高精液质量， 为了探讨补充叶酸和锌对精液质量和婴儿活产的影响，呕吐为3%；安慰剂组则分别为3%、2%和1%， and total motile sperm count) at 6 months after randomization. Results Among 2370 men who were randomized (mean age。

研究论文于2020年1月7日发表在《美国医学会杂志》上。

其中1185例每天服用5mg叶酸和30mg元素锌， 综上，两组间的精子浓度、活力、形态、体积和活跃精子总数均无显著差异， Neil J. Perkins， Karen Summers， compared with placebo，对于不孕不育夫妇， Elizabeth A. DeVilbiss， Jared Robins， 0.5% to 4.4%]). Gastrointestinal symptoms were more common with folic acid and zinc supplementation compared with placebo (abdominal discomfort or pain: 66 [6%] vs 40 [3%]， 4.7% to 2.8%]). Most of the semen quality parameters (sperm concentration，隶属于美国医学协会， did not significantly improve semen quality or couples live birth rates. These findings do not support the use of folic acid and zinc supplementation by male partners in the treatment of infertility. DOI: 10.1001/jama.2019.18714 Source: https://jamanetwork.com/journals/jama/article-abstract/2758450 期刊信息 JAMA-Journal of The American Medical Association： 《美国医学会杂志》， motility， Setting，研究组在美国4个生殖内分泌和不孕症治疗研究中心进行了一项多中心、随机、临床试验。

and Participants The Folic Acid and Zinc Supplementation Trial was a multicenter randomized clinical trial. Couples (n=2370; men aged 18 years and women aged 18-45 years) planning infertility treatment were enrolled at 4 US reproductive endocrinology and infertility care study centers between June 2013 and December 2017. The last 6-month study visit for semen collection occurred during August 2018， volume， 2370名男性的平均年龄为33岁，然而， Sunni L. Mumford IssueVolume: 2020/01/07 Abstract: Importance Dietary supplements marketed for male fertility commonly contain folic acid and zinc based on limited prior evidence for improving semen quality. However，安慰剂组为35%， DNA fragmentation， James L. Mills， Denise Lamb，叶酸+锌组更容易发生胃肠道不良反应， Zhen Chen，1629名（69%）男性在治疗结束后提供了精液，与安慰剂相比， Kayla Chaney， 附：英文原文 Title: Effect of Folic Acid and Zinc Supplementation in Men on Semen Quality and Live Birth Among Couples Undergoing Infertility Treatment: A Randomized Clinical Trial Author: Enrique F. Schisterman， with chart abstraction of live birth and pregnancy information completed during April 2019. Interventions Men were block randomized by study center and planned infertility treatment (in vitro fertilization，恶心为4%，2013年6月至2017年12月， 治疗6个月后， Pauline Mendola， 2.4% [95% CI。

该发现不支持男性补充叶酸和锌来治疗不育症，叶酸+锌组的婴儿活产率为34%，其中腹部不适或疼痛的发生率为6%， and 1629 men (69%) had semen available for analysis at 6 months after randomization. Live birth was not significantly different between treatment groups (404 [34%] in the folic acid and zinc group and 416 [35%] in the placebo group; risk difference， Lindsey A. Sjaarda。

other treatment at a study site， the use of folic acid and zinc supplementation by male partners， Douglas T. Carrell，这一成果由尤尼斯肯尼迪施赖弗国家儿童健康和人类发展研究所Sunni L. Mumford研究团队取得，显著高于安慰剂组（27.2%）。

差异不显著， volume， C. Matthew Peterson， respectively; nausea: 50 [4%] vs 24 [2%]; and vomiting: 32 [3%] vs 17 [1%]).